Molecular BiologyNature Structural & Molecular BiologyPeer-reviewed
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes…·Claire Rougeulle
The paper shows XIST reduces X chromosome activity through SPEN-dependent mechanisms before XCI in human embryos, while XACT does not significantly affect XIST function.