XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Charbel Alfeghaly, Gaël Castel, Emmanuel Cazottes, Madeleine Moscatelli, Eva Moinard, Miguel Casanova, Juliette Boni, Kasturi Mahadik, Jenna Lammers, Thomas Fréour, Louis Chauvière, Carla Piqueras, Ruben Boers, Joachim Boers, Joost H. Gribnau, , Claire Rougeulle
The paper shows XIST reduces X chromosome activity through SPEN-dependent mechanisms before XCI in human embryos, while XACT does not significantly affect XIST function.
Nature Structural & Molecular Biology · Jun 4, 2024Peer-reviewedMolecular Biology