Author

Masoumeh Hosseini

University of Wisconsin–MadisonORCID 0000-0001-8075-2277Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

André M. M. SousaiD· 2 shared Anita BhattacharyyaiD· 2 shared Daifeng WangiD· 2 shared Kalpana Hanthanan ArachchilageiD· 2 shared Pubudu KumarageiD· 2 shared Ryan D. RisgaardiD· 2 shared Sara KnaackiD· 2 shared Su-Chun ZhangiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

André M. M. SousaORCID

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2 papers

Recent·Most cited

Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex

Ryan D. Risgaard, Kalpana Hanthanan Arachchilage, Sara Knaack, Masoumeh Hosseini, Rachel J Chen, Pubudu Kumarage, Danielle K. Schmidt, Xiang Huang, Jie Sheng, Carlos J. Wang, Elisa Giusti, Shuang Liu, Su-Chun Zhang, Daifeng Wang, Anita Bhattacharyya, André M. M. Sousa

This study uses single-nucleus multiomic sequencing to analyze gene expression and chromatin accessibility in the Down syndrome prefrontal cortex, revealing widespread dysregulation in metabolic, synaptic, and neuroinflammatory pathways.

Science · Apr 23, 2026Peer-reviewedNeuroscience

Single-nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth

Nicole R. West, Kalpana Hanthanan Arachchilage, Sara Knaack, Shawn MacGregor, Masoumeh Hosseini, Ryan D. Risgaard, Pubudu Kumarage, Jose L. Martinez, Su‐Chun Zhang, Daifeng Wang, André M. M. Sousa, Anita Bhattacharyya

The paper uses single-nucleus sequencing to identify oxidative stress and metabolic changes in Down syndrome basal forebrain neurons at birth.

Alzheimer s & Dementia · Jul 1, 2025Peer-reviewedNeuroscience