Targeting MTHFD2 disrupts mitochondrial redox homeostasis and restores venetoclax sensitivity in acute myeloid leukemia
Judith O. Sokei, Orsola di Martino, Mary Basse…·Stephen Matthew Sykes
This study identifies MTHFD2 as a critical mitochondrial enzyme in AML that supports redox homeostasis and therapeutic resistance, showing that its inhibition restores venetoclax sensitivity.