Aaron R. Goldman

This paper identifies VCB1, a novel ACLY inhibitor, which overcomes TKI resistance in lymphoma by disrupting lipid and nucleotide metabolism, ISR, and redox homeostasis.

This study identifies tyrosine phosphorylation and dimerization as cooperative mechanisms activating NAMPT, enhancing NAD+ synthesis and cancer cell growth.

This study identifies RSAD2 and CMPK2 as key regulators of EBV reactivation and host interferon responses, revealing their coordinated immunometabolic role in viral latency and immune control.

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

This study identifies MTHFD2 as a critical mitochondrial enzyme in AML that supports redox homeostasis and therapeutic resistance, showing that its inhibition restores venetoclax sensitivity.

This study identifies FDXR upregulation as a prognostic marker and therapeutic target in HTLV-1-associated ATL, showing its link to disease severity and sensitivity to fluorouracil.

This study shows lamin A/C maintains genome structure and transcriptional programs needed for EBV-driven B cell activation, with loss causing chromatin reorganization and gene expression changes.

This study identifies hippuric acid as a microbial metabolite that enhances pro-inflammatory responses in macrophages via TLR-MyD88 signaling and lipid remodeling, with implications for infection and inflammation.

This study shows that Mukungulu, an African medicinal plant extract, effectively reverses HIV-1 latency in humanized mice and human cells, outperforming standard controls.

This study shows that lactate transfer via MCT1 between nucleus pulposus and endplate cells is essential for intervertebral disc health, as its absence leads to degeneration.