Stephen Matthew Sykes

Targeting MTHFD2 disrupts mitochondrial redox homeostasis and restores venetoclax sensitivity in acute myeloid leukemia

This study identifies MTHFD2 as a critical mitochondrial enzyme in AML that supports redox homeostasis and therapeutic resistance, showing that its inhibition restores venetoclax sensitivity.

Dominant negative ATP5F1A variants disrupt oxidative phosphorylation causing neurological disorders

This study identifies de novo ATP5F1A variants causing neurological disorders through dominant negative mechanisms, expanding the known phenotypic and genotypic spectrum of complex V deficiency.

Stathmin 1 regulates mitophagy and cellular function in hematopoietic stem cells

This study shows that Stathmin 1 regulates mitophagy and mitochondrial health in hematopoietic stem cells by maintaining microtubule architecture and autophagy processes.