Inhibition of ice recrystallization with designed twistless helical repeat proteins
Robbert J. de Haas, Harley Pyles, Timothy F. Huddy, Jannick van Ossenbruggen, Chuanbao Zheng, Daniëlle van den Broek, Sanne N. Giezen, Ann Carr, Asim K. Bera, Alex Kang, Evans Brackenbrough, Emily Joyce, Banumathi Sankaran, David A. Baker, Ilja Karina Voets, Renko J. de Vries
This paper designs twistless alpha-helical repeat proteins that inhibit ice recrystallization with activity comparable to native ice-binding proteins.
Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedBiophysics