Timothy F. Huddy

The paper designs de novo proteins that form autocatalytic isopeptide bonds, enabling rigid covalent protein assemblies through intramolecular and intermolecular crosslinking.

This paper designs twistless alpha-helical repeat proteins that inhibit ice recrystallization with activity comparable to native ice-binding proteins.

The paper designs proteins that template mineralization of metal-oxides, showing they can guide hematite and ZnO growth under specific conditions.