ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
Galectin-9 binding to HLA-DR in dendritic cells controls immune synapse formation and T cell proliferation
Andrea Rodgers Furones, Thijs Brands, Guusje Van Gameren…·Laia Querol Cano
This study shows that galectin-9 in dendritic cells is necessary for organizing HLA-II at immune synapses, which enhances CD4+ T cell activation and anti-tumor immunity.