Author

Daniela Hirnet

Universität HamburgORCID 0009-0004-0566-4604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Antonia BeiersdorferiD· 3 shared Christian LohriD· 3 shared Christine E. GeeiD· 2 shared Kristina SchulziD· 2 shared Natalie Rotermund· 2 shared Benjamin OndruschkaiD· 1 shared Clemens WülfingiD· 1 shared Damian Droste· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Antonia BeiersdorferORCID

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3 papers

Recent·Most cited

Crosstalk of noradrenergic Ca2+ and cAMP signaling in astrocytes of the murine olfactory bulb

Jessica Sauer, Antonia Beiersdorfer, Franz Lennart Schmidt, Mathias Nordbeck, Oana M. Constantin, Daniela Hirnet, Christine E. Gee, Christian Lohr

The paper investigates the interaction between Ca2+ and cAMP signaling in mouse olfactory bulb astrocytes, showing how different adrenergic receptors modulate these pathways.

Cell Communication and Signaling · Jul 11, 2026Peer-reviewedNeuroscience

Cell-type specific astrocyte activation is driven by cortical top-down modulation

Antonia Beiersdorfer, Kristina Losse, Jennifer Bostel, Janina Sophie Popp, Natalie Rotermund, Kristina Schulz, Damian Droste, Christine E. Gee, Daniela Hirnet, Christian Lohr

The paper investigates how astrocytes respond to bottom-up and top-down neuronal activity in the olfactory bulb, finding that top-down input from the anterior piriform cortex drives astrocytic Ca²+ signaling through sustained GC firing.

bioRxiv · Mar 9, 2026 · PreprintNeuroscience

Microgliosis, astrogliosis and loss of aquaporin-4 polarity in frontal cortex of COVID-19 patients

Antonia Beiersdorfer, Natalie Rotermund, Kristina Schulz, Miriam Busch, Daniela Hirnet, Stephan Henne, Florian L. Schwarzenberg, Matthias Dottermusch, Benjamin Ondruschka, Jakob Matschke, Clemens Wülfing, Markus Glatzel, Christian Lohr

This study examines the effects of SARS-CoV-2 infection on astrocytes and microglial cells in the frontal cortex of COVID-19 patients compared to controls, finding microgliosis, astrogliosis, and loss of AQP4 polarity.

bioRxiv · Apr 10, 2024 · PreprintNeuroscience