Cell-type specific astrocyte activation is driven by cortical top-down modulation
Antonia Beiersdorfer, Kristina Losse, Jennifer Bostel, Janina Sophie Popp, Natalie Rotermund, Kristina Schulz, Damian Droste, Christine E. Gee, Daniela Hirnet, Christian Lohr
The paper investigates how astrocytes respond to bottom-up and top-down neuronal activity in the olfactory bulb, finding that top-down input from the anterior piriform cortex drives astrocytic Ca²+ signaling through sustained GC firing.
bioRxiv · Mar 9, 2026 · PreprintNeuroscience