Divergent effects of pathological α-synuclein truncations and mutations on phase separation
Soumik Ray, Antonín Kunka, Sophie Hertel, Cecilia Chiodaroli, Katharina Schott, Azad Farzadfard, Kristina Mojtic, Louise K. Klausen, Frederik Ravnkilde Marlet, Céline Galvagnion, Alexander Kai Buell
This study shows that terminal truncations of α-synuclein significantly alter phase separation, while familial mutations have minimal effects, influencing amyloid fibril formation and condensate behavior.
Nature Communications · Jun 25, 2026Peer-reviewedBiophysics