Katharina Schott

Divergent effects of pathological α-synuclein truncations and mutations on phase separation

This study shows that terminal truncations of α-synuclein significantly alter phase separation, while familial mutations have minimal effects, influencing amyloid fibril formation and condensate behavior.

Shared and Distinct Lipid Profiles in amygdala from Sporadic and GBA-associated Parkinson's Diseases

This study identifies shared and distinct lipid profile changes in amygdala from sporadic and GBA-associated Parkinson's Disease, linking lipid metabolism to alpha-synuclein and glucocerebrosidase activity.

Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates

This study shows Ambroxol inhibits α-synuclein-lipid coaggregation by displacing α-synuclein from membranes and preventing early coaggregate formation in GBA mutation models.