Céline Galvagnion

This study shows lipidic α-synuclein fibrils catalyze the formation of mature fibrils through a heterogeneous nucleation mechanism, lowering the energy barrier and following Ostwald's Rule of Stages.

This study shows that terminal truncations of α-synuclein significantly alter phase separation, while familial mutations have minimal effects, influencing amyloid fibril formation and condensate behavior.

This study identifies shared and distinct lipid profile changes in amygdala from sporadic and GBA-associated Parkinson's Disease, linking lipid metabolism to alpha-synuclein and glucocerebrosidase activity.

This study investigates microglial metabolism and its impact on neuronal metabolism using isotope tracing and GC-MS, revealing novel metabolic functions and interactions.

This study shows Ambroxol inhibits α-synuclein-lipid coaggregation by displacing α-synuclein from membranes and preventing early coaggregate formation in GBA mutation models.

This paper develops a global kinetic model of lipid-induced alpha-synuclein aggregation and identifies how squalamine inhibits this process by reducing lipid-dependent primary nucleation.