Non-canonical stringent response signaling mediates antimicrobial fatty acid sensitivity in Staphylococcus aureus
Caitlin H. Kowalski, Sylvia B Khalil, Dante A James, T. Jarrod Smith, Killian D. Campbell, Rebecca M. Corrigan, Matthew F. Barber
This study shows that truncating the Rel protein in S. aureus enhances tolerance to antimicrobial fatty acids by altering cell envelope structure through the SigB-SarA pathway.
bioRxiv · Feb 2, 2026 · PreprintMicrobiology