ImmunologyMolecular CellPeer-reviewed
Mutability and hypermutation antagonize immunoglobulin codon optimality
Joshua J.C. McGrath, Juyeon Park, Chloe A. Troxell…·Patrick C. Wilson
The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.