Giorgio Inghirami

This study uses spatial imaging to identify architectural changes in bone marrow that predict disease activity and response to therapy in myelodysplastic neoplasms.

The paper establishes a PDX repository of large B-cell lymphoma models capturing clinical and molecular diversity, including post-CART19 progression cases.

This study demonstrates that CAR-T cells targeting mutant calreticulin can eliminate MPN-propagating HSCs in xenograft models without antigen escape.

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

This study maps human hematopoiesis at single-cell resolution, revealing aging-associated topographic remodeling in bone marrow.

This study applies low-cost whole genome sequencing to detect circulating tumor DNA at high sensitivity in plasma samples, achieving error rates as low as 10^-7 and enabling cancer monitoring without matched tumor sequencing.