Oligonucleotide synthesis errors are a source of untoward variation in HDR-mediated gene editing
Stacia K. Wyman, Zulema G. Romero, Seok‐Jin Heo, Marian S. Navarrete, Netravathi Krishnappa, Donald B. Kohn, David I. K. Martin, Mark C. Walters, Dario Boffelli
This study identifies synthesis errors in ssODNs used for HDR-mediated gene editing and shows they propagate into the genome, potentially causing disease alleles.
Genes · Jun 24, 2026Peer-reviewedGenomics