Seok‐Jin Heo

This study identifies synthesis errors in ssODNs used for HDR-mediated gene editing and shows they propagate into the genome, potentially causing disease alleles.

The paper introduces Plexus, a self-supervised model for capturing neuronal activity dynamics, and demonstrates its effectiveness in identifying genetic modifiers of neuronal activity in frontotemporal dementia.

This paper optimizes CRISPR guide RNA library cloning to reduce bias and enables more compact genetic screens with equivalent results using fewer cells.

This study uses CRISPR-Cas9 to test a putative fetal globin repressor region, finding it does not autonomously silence gamma-globin, suggesting it is not a therapeutic target for beta-hemoglobinopathies.

Cas9-mediated correction of the sickle mutation in human hematopoietic stem cells achieves curative levels of editing.