BioengineeringMolecular Therapy — Nucleic AcidsPeer-reviewed
Segmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics
Rui Qi, Hua Chen, Hui Bao…·Weiguo Zhang
This study engineers segmented poly(A) tails with microRNA target sites to enable tissue-specific regulation of mRNA-LNPs, showing position-dependent expression control in vitro and in vivo.
DOI 10.1016/j.omtn.2026.103094