Matthieu Lepage

The paper identifies β-Klotho as a novel substrate of TMPRSS6, showing that TMPRSS6 cleavage reduces KLB surface abundance and attenuates FGF19 signaling, linking TMPRSS6 to hepatic lipid metabolism.

This study identifies low nanomolar TMPRSS13 inhibitors through chemical library screening and molecular modeling, showing their ability to block SARS-CoV-2 pseudovirus entry.