The mitochondrial chaperone HSPD1 folds MTHFD2 independently of its co-chaperone HSPE1
Shani Gabbay, Hila Ben-David, Shatha S. Alassam, Linor Cohen, Tal Levy, Liron Levin, Nili Tickotsky, Ifat Abramovich, Albert Batushansky, Shiran Dror, Moshe Elkabets, Noga Alon, Yariv Brotman, Shai Kaluski-Kopatch, Evelina I. Nikelshparg, , Barak Rotblat
This study identifies HSPD1 as a chaperone for MTHFD2, independent of HSPE1, and shows distinct functional roles for HSPD1 and HSPE1 in mitochondrial biology.
Philosophical Transactions of the Royal Society B Biological Sciences · Oct 1, 2026Peer-reviewedCell Biology