Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization
Emma M. Garcia, Olivia R. Lavidor, Shaunak Raval, Nicholas Z. Lue, Jessica K. Liang, Maeve McFadden, Derek D. Hwang, M. Lisandra Zepeda, Luke W. Chen, Steven A. Carr, Malvina Papanastasiou, Brian B. Liau
This study identifies two mechanisms that rescue DNMT3A R882H activity by analyzing combinatorial mutations and showing R882H promotes aberrant oligomerization.
bioRxiv · Sep 24, 2025 · PreprintBiochemistry