Author

M. Lisandra Zepeda

Broad InstituteORCID 0009-0006-9494-6113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brian B. LiauiD· 2 shared Allison P. SiegenfeldiD· 1 shared C. GuoiD· 1 shared Caroline ComenhoiD· 1 shared Ceejay LeeiD· 1 shared Derek D. HwangiD· 1 shared Emma M. GarciaiD· 1 shared Heejin RohiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Brian B. LiauORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 24, 2025

Genetic landscape of DNMT3A R882H reveals mechanism of aberrant oligomerization

Emma M. Garcia, Olivia R. Lavidor, Shaunak Raval…·Brian B. Liau

This study identifies two mechanisms that rescue DNMT3A R882H activity by analyzing combinatorial mutations and showing R882H promotes aberrant oligomerization.

1 citation

humanproteomics

𝕏 PostBluesky

Molecular BiologyNature MethodsPeer-reviewedSep 11, 2025

Coupling CRISPR Scanning with Targeted Chromatin Accessibility Profiling using a Double-Stranded DNA Deaminase

Heejin Roh, Simon P. Shen, Hu Yan…·Brian B. Liau

This paper introduces TDAC-seq, a method combining CRISPR perturbations with chromatin accessibility profiling to study cis-regulatory elements at single-nucleotide resolution.

9 citations

humanCRISPR screen

𝕏 PostBluesky