Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice
Chengyue Ji, Yunfan Zhang, Zeyu Lin, Ziqi Zhao, Zhuolei Jiao, Zhiyuan Vera Zheng, Xiaoxue Shi, Xiaofei Wang, Ziyu Li, Yu Shuisheng, Yun Qu, Yaxuan Wei, Tan Rui, Bowen Zheng, Taorong Xie, , Yi Li
This study identifies a hypothalamic-pontine-spinal pathway that promotes locomotion and functional recovery after spinal cord injury in mice through optogenetic manipulation and deep brain stimulation.
Nature Communications · Dec 6, 2025Peer-reviewedNeuroscience