Developmental BiologybioRxivPreprint
Minor spliceosome disruption causes limb growth defects without altering patterning
Kyle D. Drake, Christopher Lemoine, Gabriela S. Aquino…·Rahul Kanadia
This study shows that disrupting the minor spliceosome, specifically by losing U11 snRNA, causes stunted limb growth without affecting limb patterning, due to increased minor intron retention and cell cycle delays.
5 citations