Molecular BiologybioRxivPreprint
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Cooperative CTCF-nucleosome oligomerization stabilizes chromatin loop anchors
Manuel Osorio‐Valeriano, Alexander C. Stone, Masahiro Nagano…·Seychelle M. Vos
CTCF dimerization on stacked nucleosomes is resolved by cryo-EM through a ZnF6-7-8 interface. Disrupting it in mouse stem cells weakens CTCF-cohesin loops more than insulation and impairs germline differentiation.