Author

Reygn Done

University of BirminghamORCID 0009-0004-7811-8313Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Alastair CoplandiD· 1 shared David A.J. LeckyiD· 1 shared David BendingiD· 1 shared Elizabeth Jinks· 1 shared Emma K. JenningsiD· 1 shared L. S. George· 1 shared Lalit PallaniD· 1 shared Lozan SheriffiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alastair CoplandORCID

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1 paper

Recent·Most cited

ImmunologyImmunotherapy AdvancesPeer-reviewedDec 30, 2024

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

Lozan Sheriff, Alastair Copland, David A.J. Lecky…·David Bending

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

5 citations

mousebulk RNA-seq

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