Author

David A.J. Lecky

University of BirminghamORCID 0000-0002-9333-5605Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Lozan SheriffiD· 3 shared Alastair CoplandiD· 2 shared David BendingiD· 2 shared Rebecca A. DrummondiD· 2 shared Sophie T. RouvrayiD· 2 shared Daisy Harris-Bosancic· 1 shared David Cameron WraithiD· 1 shared Elizabeth Jinks· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

Lozan SheriffORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyMicrobiology SpectrumPeer-reviewedFeb 2, 2026

Organ-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection

Man Shun Fu, L. George, Daisy Harris-Bosancic…·Rebecca A. Drummond

This study examines how different Cryptococcus neoformans strains affect organ-specific immune responses in a mouse model of cryptococcal meningitis, finding strain-dependent effects independent of virulence.

1 citation

mouseflow cytometry

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ImmunologyiSciencePeer-reviewedMar 31, 2025

Interferonγ and IL-27 positively regulate type 1 regulatory T-cell development during adaptive tolerance

David A.J. Lecky, Lozan Sheriff, Sophie T. Rouvray…·David Bending

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

2 citations

mousebulk RNA-seq

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ImmunologyImmunotherapy AdvancesPeer-reviewedDec 30, 2024

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

Lozan Sheriff, Alastair Copland, David A.J. Lecky…·David Bending

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky