Author

L. S. George

University of Birmingham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:transcription & RNA processing· 1

Frequent Co-Authors

Alastair CoplandiD· 1 shared David A.J. LeckyiD· 1 shared David BendingiD· 1 shared Elizabeth Jinks· 1 shared Emma K. JenningsiD· 1 shared Lalit PallaniD· 1 shared Lozan SheriffiD· 1 shared Reygn DoneiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alastair CoplandORCID

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1 paper

Recent·Most cited

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

Lozan Sheriff, Alastair Copland, David A.J. Lecky, Reygn Done, L. S. George, Emma K. Jennings, Sophie Rouvray, Thomas A.E. Elliot, Elizabeth Jinks, Lalit Pallan, David Bending

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

Immunotherapy Advances · Dec 30, 2024Peer-reviewedImmunology