Ion modulation restores local synaptic function in APOE4 neuronal networks despite persistent impairments in global network organization
Marthe Bendiksvoll Grønlie, Anna M. Kollstrøm, Axel Sandvig, Ioanna Sandvig
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Norwegian University of Science and TechnologyORCID 0009-0004-7951-5724Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Marthe Bendiksvoll Grønlie, Anna M. Kollstrøm, Axel Sandvig, Ioanna Sandvig
Anna M. Kollstrøm, Marthe Bendiksvoll Grønlie, Nicholas Christiansen…·Ioanna Sandvig
This study shows that blocking potassium channels with TEA improves synaptic stability and restores network function in ALS motor neuron networks.
Anna M. Kollstrøm, Nicholas Christiansen, Axel Sandvig, Ioanna Sandvig
This study identifies early synaptic dysfunction in ALS patient-derived motor neurons as a mechanism contributing to network-wide structural and functional compensation and vulnerability to neurodegeneration.