Ioanna Sandvig

This study investigates how APOE4 affects neuronal network structure and function, finding distinct topological and functional changes associated with Alzheimer's disease vulnerability.

This study investigates microscale and mesoscale changes in ALS motor neuron networks using in vitro models, showing increased network centralisation and rich-club connectivity as compensatory mechanisms.

This study shows that blocking potassium channels with TEA improves synaptic stability and restores network function in ALS motor neuron networks.

The paper examines how network bursts affect functional development in in vitro neural networks and suggests strategies to mitigate their impact.

This study evaluates nanoporous platinum microelectrode morphologies for neural cell cultures, finding that uniform nanoporous electrodes balance biocompatibility and electrophysiological performance.

This study identifies early synaptic dysfunction in ALS patient-derived motor neurons as a mechanism contributing to network-wide structural and functional compensation and vulnerability to neurodegeneration.

This study examines how induced P301L tau mutation alters structural and functional connectivity in engineered neural networks over time.

This study uses spatial network models to show that wiring cost and spatial clustering influence network topology, with long-range connections improving global communication and resilience to pruning.

This study develops a 3D biocompatible interface for neural networks, showing that 3D growth supports complex network structures but planar networks exhibit stronger functional interconnections and higher activity.

This study reveals structural and functional changes in human neural networks with the LRRK2 G2019S mutation using microfluidic and computational methods.

This study isolates and characterizes neural stem cells from activated neurogenic niches after traumatic brain injury in rats, finding distinct in vitro behaviors compared to uninjured controls.

This study investigates how different types of spinal cord injury affect the proliferative and neurogenic potential of neural stem cells derived from the central canal in rats.

The paper shows ALS patient-derived motor neuron networks develop cytopathology and form efficient networks with functional impairments and heightened vulnerability to perturbation.

This paper presents a microfluidic platform for creating modular cortical neural networks to study neuroplasticity and network dynamics under perturbations.

This study investigates how inhibiting excitatory synaptic transmission affects the functional organization and efficiency of in vitro neural networks, showing transient de-clustering and eventual reorganization.

This study uses microfluidic devices to control afferent-efferent connectivity in engineered neuronal networks, showing increased modularity and functional efficiency.

This study reverse engineers feedforward cortical-hippocampal neural networks using microfluidic devices to model brain network dynamics and pathology impact.

This study inhibits excitatory synaptic transmission in vitro neural networks and finds increased burstiness and synchrony over time, suggesting E/I balance is critical for normal bursting dynamics.

The paper describes a method to microdissect and culture adult entorhinal layer II neurons from AD model mice, showing they remain viable and functionally active for over two months.

This study shows that silencing superficial LEC neurons reduces intraneuronal Aβ levels in LEC and HPC in 3xTg AD mice.

This study tests repurposed drugs in a mouse model of Alzheimer's disease using intracerebral microdialysis to assess their effects on amyloid-β and tau pathology.

This study examines how inducing alpha-synuclein pathology in engineered human neural networks affects network criticality, revealing subtle changes in network function before overt symptoms appear.

This study uses in vivo microdialysis to longitudinally monitor Aβ and tau in AD mice, showing biomarker dynamics similar to human patients.

The paper presents a microfluidic platform for creating functional neuromuscular junctions using human motor neurons and myotubes, validated by rabies virus tracing.