Cornelia E. Thoeni

This paper uses Visium HD spatial transcriptomics to create a high-resolution map of human liver cell types and spatial gene expression in adult and pediatric samples.

The paper maps the multiscale structure of human liver tissue using electron microscopy and deep learning, revealing vascular, cellular, and organelle organization and dynamics.

The paper constructs a single-cell RNA-seq atlas of the human pediatric liver and identifies age-related gene signatures that differ from adult livers and are relevant to pediatric liver diseases.

This paper creates a single-cell atlas of the woodchuck liver to identify cellular programs in health and disease, showing similarities with human HBV infection.