Blayne Amir Sayed

This paper uses Visium HD spatial transcriptomics to create a high-resolution map of human liver cell types and spatial gene expression in adult and pediatric samples.

This study shows that STAT1 in myeloid cells prevents MNV-induced hepatitis and fibrosis by controlling viral spread and myeloid cell activation.

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

The paper constructs a single-cell RNA-seq atlas of the human pediatric liver and identifies age-related gene signatures that differ from adult livers and are relevant to pediatric liver diseases.

This study shows NLRP3 inflammasome activation depends on biophysical properties of acidic vesicles, not intermediate filaments, in vimentin knockout macrophages.