Ben Mulcahy

The paper maps the multiscale structure of human liver tissue using electron microscopy and deep learning, revealing vascular, cellular, and organelle organization and dynamics.

The paper identifies three muscle-specific DAF-16/FOXO targets activated by reduced insulin/IGF-1 signaling in C. elegans through transcriptomic and chromatin analyses.

The paper shows that UNC-8, an ENaC protein, promotes Ca2+-dependent endocytosis to dismantle and recycle presynaptic components during neuronal remodeling in C. elegans.

The paper investigates how two interneurons, RIS and RIM, coordinate electrical and chemical signaling to control motor state transitions in C. elegans.

The paper shows that juvenile C. elegans generate symmetric motor patterns through an asymmetric motor circuit, with dorsal bending driven by synaptic wiring and ventral bending via extrasynaptic signaling from premotor interneurons.

The paper reconstructs the post-embryonic maturation of the C. elegans motor circuit using electron microscopy, showing how structural rewiring maintains functional output during development.

The paper provides a detailed structural analysis of the anterior sensilla in C. elegans dauer larvae using FIB-SEM, revealing previously unknown neuronal structures.

This study uses connectomics to show how brain circuits change with age in C. elegans, revealing principles of brain maturation through structural and functional remodeling.

This study shows that an ALS-associated FUS mutation disrupts synaptic vesicle docking and neuromuscular transmission in C. elegans.

This study identifies a gain-of-function mutation in the UNC-2/CaV2α channel in C. elegans that causes hyperactivity and excitation-dominant synaptic transmission by altering cholinergic and GABAergic transmission.

The paper identifies functional dendritic spines in C. elegans GABAergic motor neurons and describes their structural and functional characteristics.

This paper introduces a 3D co-culture model of human skeletal muscle and motor neurons to study adult neuromuscular junction development and disease, showing increased receptor upregulation and disease modeling capability.

The paper identifies a neuroendocrine neuron, RID, in C. elegans that sustains forward movement through the neuropeptide FLP-14.