Rachel D. Edgar

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

This paper uses Visium HD spatial transcriptomics to create a high-resolution map of human liver cell types and spatial gene expression in adult and pediatric samples.

The paper constructs a single-cell RNA-seq atlas of the human pediatric liver and identifies age-related gene signatures that differ from adult livers and are relevant to pediatric liver diseases.

The paper identifies DNA methylation in the CLDN5 locus as associated with cognitive decline, independent of neuropathology, suggesting a role for the blood-brain barrier in cognitive trajectory.

This study shows that long-term culture of human intestinal organoids leads to DNA methylation changes, altered gene expression, and functional shifts, suggesting potential confounding effects in research.

BECon provides metrics to interpret blood-based DNA methylation results in the context of brain tissue using paired blood and brain samples.