Author

Diana Nakib

University Health NetworkORCID 0000-0002-4046-2109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Sonya A. MacParlandiD· 4 shared Gary D. BaderiD· 3 shared Jawairia AtifiD· 3 shared Rachel D. EdgariD· 3 shared Amanda RicciutoiD· 2 shared Blayne Amir SayediD· 2 shared Cornelia E. ThoeniiD· 2 shared Ian D. McGilvrayiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersGenomics

Sonya A. MacParlandORCID

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4 papers

Recent·Most cited

HLiCA: An integrated cell atlas of the healthy human liver

Rachel D. Edgar, Jordan R. Portman, Hongru Hu, Delaram Pouyabahar, Raza R. Rahman, Daniel Stueckmann, Yongin Choi, Drew R. Neavin, Jawairia Atif, Zoe A. Clarke, Ran Gao, Shruti Khare, Ziyi Li, Liesbet Martens, Abhishek Murti, , Gary D. Bader

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

bioRxiv · Jul 4, 2026 · PreprintGenomics

High-resolution spatial transcriptomics of adult and pediatric human liver with Visium HD

Faizan Hasan, Rachel D. Edgar, Jawairia Atif, Diana Nakib, Cornelia E. Thoeni, Amanda Ricciuto, Blayne Amir Sayed, Ian D. McGilvray, Gary D. Bader, Sonya A. MacParland

This paper uses Visium HD spatial transcriptomics to create a high-resolution map of human liver cell types and spatial gene expression in adult and pediatric samples.

Scientific Data · Jun 24, 2026Peer-reviewedGenomics

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary Fibrosis

Sayed Obaidullah Aseem, J Wang, Ahmed M. Younis, Diana Nakib, Grayson W. Way, Christiane Carter, Derrick Zhao, Yunling Tai, Xuan Wang, Emily Gurley, Sonya A. MacParland, Phillip B. Hylemon, Nidhi Jalan‐Sakrikar, Robert C. Huebert, Saul J. Karpen, , Huiping Zhou

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

bioRxiv · May 22, 2026 · PreprintPhysiology

A Single-Cell Atlas Of Human Pediatric Liver Reveals Age-Related Hepatic Gene Signatures

Rachel D. Edgar, Diana Nakib, Damra Camat, Sai Chung, Patricia Lumanto, Jawairia Atif, Cátia T. Perciani, Xue‐Zhong Ma, Cornelia E. Thoeni, Nilosa Selvakumaran, Justin Manuel, Blayne Amir Sayed, Koen Huysentruyt, Amanda Ricciuto, Ian D. McGilvray, , Sonya A. MacParland

The paper constructs a single-cell RNA-seq atlas of the human pediatric liver and identifies age-related gene signatures that differ from adult livers and are relevant to pediatric liver diseases.

Hepatology Communications · Oct 7, 2025Peer-reviewedGenomics