Glia-enriched human brain organoids for studying developmental alterations in leukodystrophies
Elisabeth Mangiameli, Liza Martha Linda Kok, Clarissa Rosato, Giovanna Cenini, Francesca Anna Cupaioli, Roberta R. Alfieri, V.P. Shreenidhi, Polina Oberst, Michael Peitz, Stephanie Dooves, Ivan Merelli, Angela Gritti, Oliver Brüstle, Vivi Majella Heine
This study uses human oligodendrocyte spheroids to model leukodystrophies and identifies disease-specific transcriptional changes and lineage-specific vulnerabilities.
bioRxiv · Oct 8, 2026 · PreprintNeuroscience