Vivi Majella Heine

This study uses human oligodendrocyte spheroids to model leukodystrophies and identifies disease-specific transcriptional changes and lineage-specific vulnerabilities.

KG-Bench benchmarks graph neural networks for drug repurposing using the Open Targets dataset, finding TransformerConv achieves the highest performance.

This study shows that gene supplementation in astrocytes of Vanishing White Matter mice improves motor skills and CNS pathology without side effects.

This study investigates how 4H leukodystrophy mutations affect cortical interneuron development using induced pluripotent stem cells and finds reduced GABAergic synapses and altered interneuron markers.

This study uses a human iPSC-derived astrocyte model to identify SCZ-specific transcriptomic and functional changes in astrocytes, revealing altered gene expression and biological processes.

The paper uses proteomic analysis of iPSC-derived neurons to identify early molecular changes in Rett syndrome, showing altered protein expression before symptoms appear.

This study generates human and mouse iPSC-derived grey and white matter-like astrocytes, revealing subtype-specific defects in Vanishing White Matter disease.