Polina Oberst

Glia-enriched human brain organoids for studying developmental alterations in leukodystrophies

This study uses human oligodendrocyte spheroids to model leukodystrophies and identifies disease-specific transcriptional changes and lineage-specific vulnerabilities.

Combined small molecule treatment accelerates timing of maturation in human pluripotent stem cell-derived neurons

This study identifies a drug cocktail that accelerates maturation of hPSC-derived neurons and other cell types through pharmacological intervention.

Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration

This study investigates the role of Sox6 in maintaining somatostatin interneuron subtype identity during migration, finding that its removal reduces subtype diversity in the mature cortex.

Apical progenitors remain multipotent throughout corticalneurogenesis

This study shows that apical progenitors remain multipotent throughout cortical neurogenesis, reverting their temporal identity and generating neurons from earlier developmental stages.

In vivo pulse-labeling of isochronic cohorts of cells in the central nervous system using FlashTag

This paper describes a protocol for in vivo pulse-labeling of newborn cells in the central nervous system using carboxyfluorescein esters, enabling tracking and isolation for downstream analysis.

Single-cell transcriptional dynamics and origins of neuronal diversity in the developing mouse neocortex

The paper traces transcriptional trajectories of progenitors and neurons during mouse neocortex development, showing how molecular states from progenitors shape neuronal diversity.