Author

Bo Lim Lee

University of PennsylvaniaORCID 0009-0004-8999-3295Unclaimed ORCID profile · follow to get notified of new preprints

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Bo Lim Lee1 paper · University of Pennsylvania

Biology Disciplines

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Biochemistry· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 1 shared Bede PortziD· 1 shared Ben E. BlackiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Cristian A BergmanniD· 1 shared Hana M. OdehiD· 1 shared

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2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ashleigh SmirnovORCID

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1 paper

Recent·Most cited

BiochemistrySciencePeer-reviewedMay 7, 2026

✦ In-depth digest

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson…·James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

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