Author

Bede Portz

Pennsylvania State UniversityORCID 0000-0002-4698-790XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Ashleigh SmirnoviD· 1 shared Ben E. BlackiD· 1 shared Bo Lim LeeiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Cristian A BergmanniD· 1 shared David S. GilmouriD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Ashleigh SmirnovORCID

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2 papers

Recent·Most cited

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson, Qizan Chen, Busra Ozguney, Marilyn Ngo, Longxin Xie, Ashleigh Smirnov, Matt Davis, Leland C. Mayne, Miriam Linsenmeier, Jack D. Rubien, Cristian A Bergmann, Bede Portz, Bo Lim Lee, , James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

Science · May 7, 2026Peer-reviewedBiochemistry✦ In-depth digest

Interplay between consensus and divergent RNA polymerase II C-terminal domain repeats in viability and targeting

Feiyue Lu, Bede Portz, David S. Gilmour

The paper shows that a truncated CTD with only YSPTSPS repeats supports Drosophila viability, while longer CTDs with more repeats are defective and localize to nuclear foci.

Molecular Cell · Feb 11, 2019Peer-reviewedMolecular Biology