Author

Ashleigh Smirnov

University of PennsylvaniaORCID 0009-0009-7843-1314Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Bede PortziD· 1 shared Ben E. BlackiD· 1 shared Bo Lim LeeiD· 1 shared Brigid K. JenseniD· 1 shared Busra OzguneyiD· 1 shared Christopher J. DonnellyiD· 1 shared Cristian A BergmanniD· 1 shared Hana M. OdehiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Bede PortzORCID

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1 paper

Recent·Most cited

BiochemistrySciencePeer-reviewedMay 7, 2026

✦ In-depth digest

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Katie E. Copley, Jocelyn C. Mauna, Helen L. Danielson…·James Shorter

Short UG-rich RNAs bind and stabilize TDP-43 RNA-recognition motifs to allosterically destabilize its prion-like domain helical region, preventing aggregation and mitigating neurodegeneration in cells and mice.

20 citationstop 1%

humanmouse

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