Sympathetic Nervous System Overactivation Induces Colonic Eosinophil-Associated Microinflammation and Contributes to the Pathogenesis of Irritable Bowel Syndrome
Shaoqi Duan, Hirosato Kanda, Feng Zhu, Masamichi Okubo, Taro Koike, Yoshiya Ohno, Toshiyuki Tanaka, Yukiko Harima, Kazunari Miyamichi, Hirokazu Fukui, Shinichiro Shinzaki, Yilong Cui, Koichi Noguchi, Yi Dai
This study shows that sympathetic nervous system overactivation in a maternal separation model leads to colonic eosinophil infiltration and visceral hypersensitivity, contributing to IBS pathogenesis.
bioRxiv · Jul 22, 2024 · PreprintNeuroscience