Kazunari Miyamichi

Stressor-Selective Sympathetic Preganglionic Modules for Organ-Biased Control

The paper identifies stressor-selective sympathetic preganglionic modules in mice that link physiological demands to organ-biased sympathetic output.

A single-nucleus and spatial transcriptomic atlas of the Syrian hamster preoptic area across hibernation states

This study creates a transcriptomic atlas of the Syrian hamster preoptic area using snRNA-seq and spatial transcriptomics, comparing seasonal and hibernation states.

A vagal sensory pathway for satiety suppression by intestinal fructose

The paper identifies a vagal sensory pathway activated by intestinal fructose that does not suppress food intake, unlike glucose, potentially contributing to overconsumption of fructose.

Transcriptomic Landscape of Microglia in Mouse Models of Social Dysfunction and Oxytocin-Mediated Recovery

The paper investigates how VPA exposure and OT neuron stimulation affect microglia in the PVH and finds that OT neuron activation can reverse some microglial gene downregulation.

Hypothermic Conditions Impair GnRH Pulse Generator Activity and Gametogenesis

This study shows hypothermia, not hypometabolism, suppresses reproductive activity in mice by reducing arcuate kisspeptin neuron activity during energy-saving conditions.

A neuronal population in the bed nucleus of the stria terminalis mediating pup-directed aggression in male mice

The paper identifies BSTpr Cartpt+ neurons as mediators of pup-directed aggression in male mice and shows their role in the transition to parental care.

Vasopressin-to-Oxytocin Receptor Crosstalk in the Preoptic Area Underlying Parental Behaviors in Male Mice

The paper identifies vasopressin-to-oxytocin receptor crosstalk in the preoptic area as a key mechanism for paternal caregiving behaviors in male mice.

Artificially induced torpor during pregnancy impairs fetal growth in mice

This study shows that artificially induced hypothermia during pregnancy in mice causes fetal growth impairment and pregnancy loss, highlighting the importance of maternal body temperature in fetal development.

Submedius Thalamus Modulates Orbitofrontal Cortex Representations During Maternal Behavior in Mice

The paper identifies the submedius thalamus (SMT) as a presynaptic partner of the orbitofrontal cortex (OFC) in mice, showing its role in modulating maternal behavior through experience-dependent plasticity.

Dissecting Medullary Raphe Neurons Regulating Multiple Thermogenic Pathways

This paper identifies RPa-vGluT3 neurons as critical regulators of thermogenesis by coordinating sympathetic and somatic motor outputs to increase body temperature.

Neural Circuit Remodeling Underlying Enhanced Feeding During Pregnancy in Mice

The paper shows pregnancy in mice reduces excitatory inputs to PVH oxytocin neurons, promoting increased food intake by dampening their anorexigenic activity.

Orbitofrontal Cortex Influences Dopamine Dynamics Associated with Alloparental Behavioral Acquisition in Female Mice

This study shows that the orbitofrontal cortex promotes alloparental caregiving in female mice by modulating dopamine dynamics during behavior acquisition.

A skeletal muscle-sympathetic nerve-intestine network underlies muscle inflammation and atrophy induced by immobilization

This study identifies a muscle-sympathetic nerve-intestine network that drives inflammation and atrophy in immobilized muscles, showing that intestinal inflammation contributes to muscle damage.

Dietary Availability Acutely Governs Puberty Onset via Hypothalamic Neural Circuit

This study shows that dietary availability affects puberty onset in female mice by modulating the activity of arcuate kisspeptin neurons through a neural circuit involving Agrp neurons.

Opioidergic activation of descending pain inhibitory system underlies placebo analgesia

The paper shows that opioidergic signals in the medial prefrontal cortex activate the descending pain inhibitory system to initiate placebo analgesia in neuropathic pain rats.

Flexible Adjustment of Oxytocin Neuron Activity in Mother Mice Revealed by Microendoscopy

This study uses microendoscopic imaging to show dynamic changes in oxytocin neuron activity in mother mice during lactation and weaning, revealing flexible adjustments in single-cell activity patterns.

Parallel Labeled-Line Organization of Sympathetic Outflow for Selective Organ Regulation in Mice

The paper identifies two molecularly distinct subtypes of sympathetic preganglionic neurons in mice that selectively regulate gastrointestinal and adrenal functions through non-overlapping innervation patterns.

Selective Vulnerability of Parvocellular Oxytocin Neurons in Social Dysfunction

The paper shows that social dysfunction in mice is linked to selective gene expression impairment in parvocellular oxytocin neurons, which can be mitigated by neonatal chemogenetic stimulation.

Sympathetic Nervous System Overactivation Induces Colonic Eosinophil-Associated Microinflammation and Contributes to the Pathogenesis of Irritable Bowel Syndrome

This study shows that sympathetic nervous system overactivation in a maternal separation model leads to colonic eosinophil infiltration and visceral hypersensitivity, contributing to IBS pathogenesis.

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

This study identifies CaMKII-dependent activity of cortical parvalbumin neurons as essential for homeostatic sleep rebound following prolonged wakefulness.

Dynamic Modulation of Pulsatile Activities of Oxytocin Neurons in Lactating Wild-type Mice

The paper develops a Cre-free method to monitor oxytocin neuron activity in lactating mice and shows that pulsatile activity depends on mother-pup contact.

Dynamics of Pulsatile Activities of Arcuate Kisspeptin Neurons in Aging Female Mice

This study uses chronic in vivo Ca2+ imaging to track pulsatile activity of kisspeptin neurons in aging female mice, revealing robust frequency patterns but declining intensity during reproductive senescence.

Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice

This study shows that oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice by reducing food intake and increasing plasma triglyceride and leptin levels.

Recording and Manipulation of the Maternal Oxytocin Neural Activities in Mice

The paper records and manipulates maternal oxytocin (OT) neural activities in mice using fiber photometry and identifies plasticity and modulatory circuits.

Plasticity of Neural Connections Underlying Oxytocin-mediated Parental Behaviors of Male Mice

The paper identifies oxytocin neurons as key regulators of paternal caregiving in male mice and shows enhanced excitatory connections from lateral hypothalamus neurons in fathers.

Realization of phosphorylation hypothesis of sleep by mammalian CaMKIIβ

This study shows that CaMKIIβ phosphorylation regulates sleep duration and steps in mammals by modulating kinase activity in excitatory neurons.

CUBIC-Cloud: An Integrative Computational Framework Towards Community-Driven Whole-Mouse-Brain Mapping

CUBIC-Cloud is a cloud-based framework for analyzing and integrating whole mouse brain data, demonstrating applications in cell distribution, plaque quantification, neuronal activity, and connectivity mapping.

GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice

The paper identifies a novel GABAergic neuron population in the olfactory cortex of mice that project to the lateral hypothalamus and integrate olfactory and top-down inputs.