This study identifies an ADP-ribosyl-cysteine degron in PARP7 that is recognized by DTX2, leading to PARP7 degradation and affecting AR signaling in prostate cancer.

bioRxiv · Oct 28, 2026 · PreprintBiochemistry

PARP1 regulates establishment of the ovarian reserve and age at natural menopause

Hannah R. Schorle, Jason Alexander Halliwell, Jonas Damgaard Elsborg, Stasa Stankovic, Emily J Morbey, Jack R A Murzynowski, Amy V. Kaucher, Ruiqi Sun, Michael Lund Nielsen, Kathleen R. Stewart-Morgan, Anna Murray, Jesper Velgaard Olsen, John R. B. Perry, Eva R. Hoffmann

This study identifies a variant in PARP1 associated with earlier menopause by affecting primordial germ cell fate through altered DNA binding and transcriptional regulation.

medRxiv · Jun 18, 2025 · PreprintGenetic & Genomic Medicine

Structure and mechanism of Zorya anti-phage defense system

Haidai Hu, Thomas C.D. Hughes, Philipp F. Popp, Aritz Roa-Eguiara, Freddie J. O. Martin, Nicole R. Rutbeek, Ivo Alexander Hendriks, Leighton J. Payne, Yumeng Yan, Victor Klein-Sousa, Yong Wang, Michael Lund Nielsen, Richard Michael Berry, Marc Erhardt, Simon A. Jackson, Nicholas M. I. Taylor

This study reveals the structure and mechanism of the Zorya anti-phage defense system using cryo-EM and functional assays, showing how it detects phage invasion and activates defense.

bioRxiv · Dec 18, 2023 · PreprintMolecular Biology

N-terminal toxin signal peptides efficiently load therapeutics into a natural nano-injection system

Eva Maria Steiner, Rooshanie N. Ejaz, Claudia S. Kielkopf, Mar Pérez‐Ruiz, Leyre Marín-Arraiza, Ivo Alexander Hendriks, Jakob Nybo Nissen, Irina Pozdnyakova, Tillmann Pape, Alice Regaiolo, Kira Götz, Ralf Heermann, Simon Rasmussen, Michael Lund Nielsen, Nicholas M. I. Taylor

This study identifies an N-terminal signal peptide that enables efficient loading of therapeutics into the Afp nano-injection system for targeted delivery.

bioRxiv · Nov 13, 2023 · PreprintMolecular Biology

DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network

Massimo Carraro, Ivo Alexander Hendriks, Colin M. Hammond, Victor Solis‐Mezarino, Moritz Carl Völker-Albert, Jonas Damgaard Elsborg, Melanie Bianca Weisser, Christos Spanos, Guillermo Montoya, Juri Rappsilber, Axel Imhof, Michael Lund Nielsen, Anja Groth

The paper identifies DAXX as a novel histone chaperone pathway that deposits H3.3K9me3 before DNA deposition, expanding the histone chaperone network's role in heterochromatin assembly.

Molecular Cell · Mar 2, 2023Peer-reviewedMolecular Biology