Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
Abigail J. Clevenger, Claudia A. Collier, John Paul M. Gorley, Sarah Colijn, Maygan K. McFarlin, Spencer C. Solberg, Scott Kopetz, Amber N. Stratman, Shreya A. Raghavan
This study shows that oncogenic KRAS mutations in colorectal cancer cells lead to a unique mechanotransduction response to peristalsis, increasing cancer stem cell enrichment and tumorigenicity.
Molecular Cancer Research · Nov 1, 2024Peer-reviewedBioengineering