Matthew J. Ming

The paper identifies twelve genes with consistent sex differences in allele frequencies across three studies and proposes hypotheses for the mechanisms driving these differences.

The paper challenges the hypothesis that sex-differential gene expression drives sex-differential selection by showing no genome-wide relationship between sex differences in expression and selection on eQTLs across 39 human tissues.

This study quantifies sex-differential selection (SDS) across the human genome using UK Biobank data, revealing polygenic signals and a tradeoff between viability and fecundity.

The paper identifies amplification as the main mechanism of gene-by-sex interactions in complex human traits, showing sex differences in genetic effect magnitudes rather than variant identity.