Author

Chunlei Chen

Northwestern UniversityORCID 0009-0005-1925-7644Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hossein ArdehaliiD· 2 shared Hsiang‐Chun ChangiD· 2 shared Jason Solomon ShapiroiD· 2 shared Yuki TatekoshiiD· 2 shared Amir MahmoodzadehiD· 1 shared Davi M. Lyra‐LeiteiD· 1 shared Malorie BlancardiD· 1 shared Maryam BalibeglooiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Hossein ArdehaliORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced diastolic dysfunction

Yuki Tatekoshi, Chunlei Chen, Jason Solomon Shapiro, Hsiang‐Chun Chang, Malorie Blancard, Davi M. Lyra‐Leite, Paul W. Burridge, Matthew J. Feinstein, Richard T. D’Aquila, Priscilla Y. Hsue, Hossein Ardehali

This study uses hiPSC-CMs to model inflammation-induced diastolic dysfunction in HIV patients and tests drug effects on calcium transient.

eLife · Mar 28, 2024Peer-reviewedMolecular Biology

SIRT2 inhibition protects against cardiac hypertrophy and heart failure

Xiaoyan Yang, Hsiang‐Chun Chang, Yuki Tatekoshi, Amir Mahmoodzadeh, Maryam Balibegloo, Zeinab Najafi, Rongxue Wu, Chunlei Chen, Tatsuya Sato, Jason Solomon Shapiro, Hossein Ardehali

This study shows that SIRT2 inhibition reduces cardiac hypertrophy and heart failure in mice by modulating NRF2 activity and antioxidant defenses.

eLife · Sep 20, 2023Peer-reviewedMolecular Biology