Olivier Dennler

OrthoGather provides a user-friendly platform for comparative proteomic analysis and Gene Ontology enrichment across species, enabling functional interpretation of protein sets without computational expertise.

The paper evaluates sequence and structural similarity metrics for predicting shared paralog functions using synthetic lethality and protein-protein interactions.

The paper shows that gene loss in cancer is often compensated by paralog protein abundance changes, stabilizing protein-protein interaction networks and creating therapeutic vulnerabilities.